UpToDate Lexidrug Content Sets and Tools

• Our most extensive content set, Lexi-Drugs® provides clinicians in-depth information on: adverse reactions, Canadian brand names, dosing, FDA special alerts, medication safety issues, pharmacodynamics/kinetics, and more than 500,000 brand names from over 150 countries. Lexi-Drugs provides unique information for different patient populations, including expanded dosing information for hepatic, renal, obesity, neonatal, and more, as well as information tailored to the needs of the following clinical specialties: pharmacy, nursing, internal medicine, cardiology, oncology, psychiatry, anesthesiology, and dentistry. Lexi-Drugs is also a Centers for Medicare & Medicaid Services (CMS)-approved compendium for off-label oncology uses of drugs.  
  
  
• Lexi-Drugs Multinational content set gives clinicians access to extensive information on drugs available outside the United States. Lexi-Drugs Multinational is structured similarly to Lexi-Drugs and delivers the same enhanced content such as  renal, hepatic, obesity, neonatal, and other dosing and dosage forms, adverse drug reactions, a quick look-up of more than 500,000 international brand names across 150 countries, and much more.

Evidenced-based and fully referenced, our neonatal-specific content is located within the Pediatric & Neonatal Lexi-Drugs database. This database is intended to help clinicians make safe neonatal dosing decisions and enhance patient care. It offers timely drug information for this vulnerable patient population compiled from a broad array of trusted sources. The database contains more than 300 professional drug monographs with up to 45 fields of information, including dosing information for neonates and infants, pregnancy and lactation information, usual concentration, drug interactions, IV compatibility, and more.

With content developed by industry-leading Wolters Kluwer application Facts and Comparisons®, the Facts and Comparisons Off-Label database provides in-depth information on off-label uses along with valuable context to inform decision making. Search the database or link to it from the off-label uses field in hundreds of Lexi-Drugs core drug monographs to find evidence ratings and information on therapy considerations, dosing and population studies, risk/benefit discussion, and more.

Physicians and pharmacists can review comparative efficacy studies for individual drugs and drug classes when choosing a particular drug over another for a specified disease or condition—allowing clinicians to more easily review clinical evidence when making a determination about the relative efficacy of different drug therapies.

AHFS Essentials provides quick access to an additional source for in-depth, evidence-based drug information—including off-label uses—that helps clinicians answer tough questions at the point of care. Search this database, and link directly to AHFS drug monographs from within UpToDate Lexidrug.

AHFS Drug Information provides quick access to an additional source for in-depth, evidence-based drug information—including off-label uses—that helps clinicians answer tough questions at the point of care. Search this database, and link directly to AHFS DI Essentials drug monographs from within UpToDate Lexidrug. Recognized as an official compendium by the U.S. Congress, AHFS Drug Information is the only drug information resource published by a professional scientific association.

Martindale gives clinicians quick and easy access to in-depth information on pharmaceutical products available worldwide. Accessible within UpToDate Lexidrug, Martindale provides an unrivaled, globally focused resource for identifying medications, local equivalents, manufacturers, and more.

Nursing Lexi-Drugs provides nurses and nursing students extensive clinical information for use at the point of care. Key fields of information include administration, monitoring, IV compatibility and reconstitution instructions, dosing, and patient education.

This natural products database provides clinicians valuable information on more than 460 commonly used natural products. Peer reviewed by an expert panel, professional monographs include in-line referencing and information on dosage, source, adverse reactions, uses and pharmacology, toxicology, pregnancy/lactation, and other key information.

Clinicians can use the information provided in this database to help diagnose and treat infectious diseases more effectively and efficiently. Specific clinical information includes combining disease syndromes, organisms, diagnostic tests, and antimicrobial therapy. Professional monographs for anthrax, botulism, smallpox, ebola, and other potential agents of bioterrorism are included.

UpToDate Lexidrug provides access to both Summary Pharmacogenomics monographs, as well as an in-depth Pharmacogenomics database to provide a foundation for clinicians who will be called on to integrate rapidly expanding genomic knowledge into the management of drug therapy. Summary Pharmacogenomics focuses on a single drug or drug class for quicker access to actionable content for clinical use at the point of care. Summary monographs include management considerations, summary discussion of scientific and clinical studies data, quality of evidence ratings, and links to the in-depth database to support deeper research. The Pharmacogenomics database provides detailed information concerning key genetic variations that may influence drug disposition and/or sensitivity, including incidence, variability across population, pathophysiologic information, and more.

The most extensive UpToDate Lexidrug dental drug information database, Dental Lexi-Drugs provides quick access to timely dental-specific information at the point of care. Designed for the busy dental professional, Dental Lexi-Drugs monographs include key dental health fields such as local anesthetic/vasoconstrictor precautions, effects on dental treatment, and dental dosing for selected drug classifications.

Geriatric Lexi-Drugs provides clinicians in-depth information on drug interactions and drug dosing in elderly and adult populations, as well as dosing adjustments for patients with renal/hepatic impairment. This specialized database contains more than 990 geriatric-sensitive professional drug monographs, supplying up to 44 key fields of information.

Featuring content from the highly respected Briggs’ Drugs in Pregnancy and Lactation, this database complements our proprietary Pregnancy & Lactation monograph fields in Lexi-Drugs and increases the breadth and depth of information related to medication safety and appropriate drug use during pregnancy and breast-feeding. Featuring more than 1,000 monographs, the Briggs’ database provides information on a drug’s pharmacologic category and summaries of precautions and appropriate uses related to pregnancy, fetal risk, and breast-feeding. It also includes pregnancy and breast-feeding recommendations with links to definitions and in-line reference links to PubMed.

Drug Allergy and Idiosyncratic Reactions addresses drug allergies, including reactions by drug class, considerations when managing patients with reported allergies, and more. This innovative database is based on integration of scientific and clinical literature and offers unique insight on allergic mechanisms, concepts and categorizations. In addition, this database discusses idiosyncratic reactions which may be confused with allergy, either due to clinical presentation or patient-reported events. This data will assist the clinician in addressing allergy-related issues which are often difficult to interpret in clinical practice.

This extensive drug, drug allergy, and herbal interaction analysis tool assists clinicians in making safer medication decisions at the point of care. Accessible from the blue toolbar, the Interactions tool allows clinicians to enter a patient's entire regimen and known drug allergies, identify potential interactions, and obtain appropriate patient management steps. The analysis includes a summary of drug interactions with an assigned risk rating to identify the action steps necessary. Each letter designation (A, B, C, D, X) represents the severity level of the identified interaction. A detailed interaction monograph is displayed by clicking on the interacting drug name.

Drug ID helps clinicians quickly identify unknown or unlabeled medications based on parameters such as imprint, dosage form, shape, and color. Powered by Medi-Span® data, clinicians have access to more than 13,00 unique images and nearly 58,000 unique imprints to help identify medications. Link to full drug monographs and additional support content when necessary.

The calculators tool assists clinicians in making drug calculations and decisions for treating specific patient conditions. This module features nearly 200 medical formulas, clinical criteria sets, and decision tree analysis tools, including calculators from MedCalc 3000 as well as exclusive calculators unique to UpToDate Lexidrug offerings. Accessible directly from the UpToDate Lexidrug tool bar as well as fully integrated within the Lexi-Drugs database, calculators address weight-based pediatric ALS, dosing, dosing conversions, drip rates, organ function, TPN osmolarity determination, APGAR scoring, Child Pugh Classification, kidney filtration, and other issues for both adults and children.

IV Compatibility module provides clinicians quick access to the Trissel's™ 2 Clinical Pharmaceutics Database by Lawrence A. Trissel to help them reduce risk and support safe IV compatibility decisions at the point of care. User-friendly and accessible from the blue UpToDate Lexidrug toolbar, the IV Compatibility tool offers real-time updates as new content is available, the ability to search by drug and by IV solution, in-depth content on the properties of more than 850 drugs and solutions, and over 76,500 compatibility results supported by more than 4,700 unique references.

Using the drug comparisons tab in the blue toolbar, physicians and pharmacists can access two ways to compare a variety of data points: Monograph view allows you to compare four drug monographs side-by-side, and data view allows you to build a customized table comparing up to four drugs.

The patient education module helps clinicians enhance compliance and reduce readmissions by providing patients with a wide range of easy-to-read information (written at a 5th-to-7th-grade reading level) about their condition, treatments, and overall health. Our patient education handouts support compliance with Joint Commission standards and cover information on medications (adult and pediatric), diseases and conditions, labs and procedures, natural products, dental topics, occupational and physical therapy, discharge instructions, and health and wellness. Handouts are available in up to 19 languages and can be customized with the patient's name and clinician information.

Lexi-Drug Plans® provides the formulary status of medications for more than 5,500 prescription drug plans, including Medicare and Medicaid. This module may be customized, managed, and edited by an on-site client administrator.

Designed for healthcare professionals working in emergency and first-response situations, the Toxicology module provides immediate support for the assessment, diagnosis and treatment of exposures and overdoses. It includes the Lexi-Tox database and a Household Products database, which combine to provide information on agents of toxicity, antidotes and decontaminants, and household products, as well as access to Material Safety Data Sheets (MSDS), toxicology-specific calculators, and drug identification in one essential tool.