I.V. Compatibility

Click on "Trissel's IV Compatibility" to open the module.

To search compatibility information from the Trissel's™ 2 Clinical Pharmaceutics Database by Lawrence A. Trissel, begin by typing the desired drug or solution name into the appropriate search box. Possible drug/solution selections will be displayed as you continue to type. Select a drug by clicking the enter key on your keyboard or by using the Add button. Enter solutions into the Selected Items field in the same manner. You will need to enter at least 2 drugs or at least one drug and solution into the respective search boxes to check on compatibilities. The selected drug(s) and solution(s) will populate the Selected Items in the left pane. Once the desired items have been entered, click the blue Analyze button to perform the compatibility check.

The results will be presented in a table with the drugs in both horizontal and vertical axis. Solutions, if selected, will be listed underneath the drugs on the vertical axis. To locate the results of a desired drug-drug or drug-solution pair, follow the horizontal and vertical axis to find where they intersect. The field will contain the different compatibility tests available for the desired pair. The tool will display all compatibilities alone in the default view. To filter the compatibility types to only view Y-site compatibilities, change the filter in the upper right pane from “All methods” to “Y-Site only."

Definitions for the following types of compatibility testing are as follows:

  • Y-site Compatibility - A single drug that is administered simultaneously at a Y-site connection with another drug in a solution
  • Solution Compatibility - A single drug in a solution
  • Admixture Compatibility - Two drugs in a solution
  • Syringe Compatibility - Two drugs in a syringe

The compatibility information presented is based on one of four (4) ratings:

Compatible

  • No change in visible or electronically determined particulates, haziness or turbidity, frank precipitation, color, or evolution of a gas.
  • All drug components in the test samples were found to be chemically stable (less than 10% loss of intact drug) for at least 24 hours under the conditions being tested.
  • All drug components in the test samples were found to be chemically stable (less than 10% loss of intact drug) for the entire period of the study under the conditions being tested, even if the study period was less than 24 hours.

Incompatible

  • A change in visible or electronically (even if not visible) particulates, haziness, or turbidity, frank precipitation, color or gas evolution occurred.
  • One or more drug components in the test samples exhibited a loss of intact drug greater than 10% within 24 hours under the conditions being tested.

Uncertain or Variable

For research results that do not fit these conventional guidelines, the research results are designated as Uncertain or Variable. Apply judgment in using these results. Examples include:

  • A transient precipitation formed upon mixing but then disappeared. The precipitate may or may not show up again later.
  • Among repeat test samples, microparticulate formation was electronically determined to have formed in some samples but not others.
  • The test drug in a solution was stable in one container type but not another or with some drug delivery devices but not others.
  • Compatibility of a drug(s) is dependent on the manufacturer(s) of the products and/or the use of specific product formulations.
  • When both compatible and incompatible study results are available for the same drug pair. Many of these may be due to differences in concentrations of either drug or in the solution diluent.
  • Any other research result that does not fit the conventional guidelines of compatibility or incompatibility.

No data

  • No data for administration methods chosen.

Click on the rating link in the table to obtain additional details on the compatibility study(s), including a summary of the study methods and primary references for the compatibility information as appropriate. If multiple studies are available, click on the desired link within either the Study or Finding columns. The tabs at the top of the page will return you to the Compatibility Chart or the Search page.

To see the specific properties for a particular drug or solution, click on the name of the drug or solution in the Selected Items list. This will open a tab that provides the properties information available for that drug or solution. Properties may include: formulation or reconstitution information, stability and storage information, light effects, pH, and various other information.

You can click on the Search tab at any time to enter new drugs to be screened. New items will appear in the Selected Items field. To remove an individual drug or solution, click on the X next to the name. To clear the items from the tool, click the Clear button.