Clinical decisions aren’t always black-and-white—and neither are clinical questions. UpToDate® Expert AI delivers fast, reliable answers through a conversational experience that feels like consulting a trusted colleague. Purpose-built for today’s clinicians, it combines the power of generative AI with rigorously vetted, expert-authored content from UpToDate —connecting users to the clinical intelligence needed to make confident, informed care decisions.
Now available in personal trainee subscriptions and UpToDate Pro Plus subscriptions in the US and Canada, and through select Enterprise Edition accounts.
A clinical partner, grounded in human expertise
UpToDate® Expert AI is generative AI built solely on curated, evidence-based clinical content, delivering the nuance, context, and speed clinicians need for actionable, real-world care decisions. Get fast, clear answers to help guide decisions for complex cases, treatment plans, differential diagnoses, drug dosing, and more.
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Clinical guidance
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Transparent reasoning
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Tailored responses
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Latest features
Support safe care with the GenAI solution built by clinicians, for clinicians.
UpToDate Expert AI delivers trusted insights grounded in the evidence-based recommendations from over 7,600 clinicians, and built with rigorous AI standards that prioritize transparency, evidence, and clinical integrity. Ask questions and get clear, traceable answers that include inline links to UpToDate topics.
Features that connect responses to UpToDate content and clinical expertise:
- Succinct answers for faster action, with the option to refine questions or ask a follow-up.
- UpToDate Sources and inline links provide clear citations and displays the supporting UpToDate content without leaving the AI search interface.
- Assumptions provide context and inline nudges help guide clinicians toward asking improved questions for better answers.
- Drug linking provides relevant drug information in a side panel.
- Voice input for hands-free questions.
Designed to support clinical reasoning, not replace it.
Engage in interactive dialogue that delivers more than just insights. Every response from UpToDate Expert AI includes transparent reasoning and clearly stated assumptions, helping you understand not only the recommendations provided, but the rationale behind them.
Features that promote transparency and clinical reasoning:
- Assumptions frame the question and clarify the clinical problem.
- A side panel provides supporting links, rationale, facts, and UpToDate topics without leaving workflow.
- Nudges help clinicians add missing context, like comorbidities or ICU status.
- Inline sources show referenced UpToDate topics tied directly to statements.
Elevate your clinical decision-making with tailored recommendations.
Get nuanced support for working through cases, interpreting evidence, determining care options, and applying insights to patient care. Designed to think like a clinician, UpToDate Expert AI empowers your clinical judgment without replacing it.
Features that support fast understanding and clinical decision making:
- Succinct, high-quality responses clearly organized into assumptions, direct answers, and clinical context.
- Tailored visuals simplify complex clinical content.
- Structured tables help compare care options, such as differential diagnoses.
- Drug information that’s relevant and doesn’t require sifting through monographs.
Always UpToDate
UpToDate Expert AI is constantly evolving through groundbreaking advancements and thoughtful refinements to ensure it remains a trusted, provider-focused solution. With every update, we’re committed to delivering smarter, faster responses that empower clinicians to provide safe, exceptional care.
Our latest updates are:
- Recent GenAI search enhancements to support more actionable care include: reformatted responses, adding nudge prompts to trigger additional context, inline sources, structured answers, voice prompts.
- A side panel provides UpToDate cited sources, drug monographs, dosing details, and graphics within your search interface.
- Expanded CME/CE/CPD credit accrual to UpToDate Expert AI to support professional development within the workflow.
- Expanded medication information from UpToDate Lexidrug to support .high-impact drug-related questions, such as adverse reactions, contraindications, and considerations for pregnancy and breastfeeding.
- Added copy-and-paste functionality to make it easier for clinicians to seamlessly integrate UpToDate insights into their workflows.
Report: Shadow AI tool use in healthcare organizations
41% of respondents were aware of colleagues using unauthorized AI tools
17% said they had used an unauthorized tool
Shadow AI occurs when unauthorized AI tools are used across organizations, introducing risk to data, security, and privacy. Leaders at healthcare organizations need to understand how prominent these risks are and take an enterprise approach to AI solutions.
A Wolters Kluwer Health survey of healthcare providers and administrators assessed shadow AI tool usage and the perceived risks of AI solutions. Explore the survey data and actionable steps in the whitepaper, “Shadow AI: A hidden risk to healthcare.”
The latest insights on AI from UpToDate
Conversations on AI & innovation in healthcare
Explore expert-led podcast interviews from UpToDate experts on AI, clinical workflows, and the future of healthcare, offering a thoughtful look at how technology is shaping evidence-based care.
Listen To The PodcastsBuilding the bridge: GenAI and clinical knowledge
Get a special report by Dr. Sheila Bond on how UpToDate is bridging the rigor of clinical knowledge and GenAI innovations. Read our philosophy and the systems built to make GenAI clinically dependable and validated for the point of care.
Read The WhitepaperIn the GenAI era, care delivery relies on trust and efficiency
With trusted, evidence-based clinical intelligence embedded across your health system, your teams can make care decisions confidently in the new era of healthcare.
Read Our Vision
“UpToDate Expert AI is a smarter, faster way to deliver trusted answers—right when clinicians need them. It’s a natural extension of how we deliver care: quick, reliable, and evidence-based.”
Charles J. Sonday, DNP
Associate Chief Medical Information Officer
St. Luke’s University Health Network
Associate Chief Medical Information Officer
St. Luke’s University Health Network
Clinical intelligence—like having a peer at your side
“In the UpToDate Expert AI, it’s like I’m having conversations that suggest the next question that I should be thinking of, and I find that really helpful.”
— Physician Assistant, Primary Care
Trusting the content
“If I can trust UpToDate to begin with, then getting an AI-powered summary that's coming right from UpToDate—and nowhere else—is going to allow for that increased trust. It's an exciting direction we're heading in.”
— Clinician, Internal Medicine, 5 years of practice
Augmenting clinician judgment
“I want supportive decisions as opposed to automated decisions. I'd rather have tools that support my decision-making as opposed to creating it for me and looking for a checkoff that I approve.”
— Physician Assistant, Tier 1 university health system
Transparency in generated responses
“Compared to other products, the transparency in UpToDate Expert AI is 1A. The assumptions section—where it says ‘I’m assuming this patient is not pregnant, not a child, doesn’t have major comorbidities’—puts it above all the other tools I’ve tried.”
— Medical Librarian
An established trust in UpToDate
“I trust UpToDate. And that level of trust allows me to know that if this is an UpToDate product, I know it's been rigorously tested and it's showing me what it's supposed to show me.”
— Clinician, Internal Medicine, 10 years of practice
Explore more on the future of AI in clinical decision support
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Key Challenges
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Whitepapers
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Our Expertise
A generational shift in the workforce
The intersection of innovation, generational workforce shifts, and the emergence of GenAI is driving a new era of clinical information retrieval. Access point-of-care insights.
Get The UpToDate ReportShifting patient expectations
Patients expect more involvement in their care. Including the patient on the care team, with shared, AI-enabled evidence at the center, equips teams for more aligned decisions.
Read The Expert InsightManaging risk and shifting regulation
As healthcare professionals increasingly use GenAI tools in administrative work and at the point of care, leaders must implement usage policies to minimize risk to security and patient care.
Read The Expert InsightHealthcare AI shouldn’t be an ‘either-or’ decision
AI in clinical decision support solutions shouldn't mean compromising between speed, evidence, and trust. Deliver AI solutions that enhance decision-making without tradeoffs.
Read The WhitepaperIntegrating responsible clinical generative AI at the point of care
Artificial intelligence tools represent an exciting new frontier in healthcare, but identifying a responsible, expert content partner is key to clinician adoption.
Access The WhitepaperThe role of real-world evidence in informing clinical decision-making
Numerous AI-powered tools are now available to support clinicians. Health leaders must determine which can cut through the noise to provide the latest evidence-based information for teams.
Access The WhitepaperInnovate responsibly: Cutting through the GenAI hype
In the fast-moving world of GenAI, it’s easy to get caught up in the allure of new technologies. But Dr. Holly Urban says we can’t let hype outpace responsibility without careful vetting.
Read On HIStalkSeeing clinical value from AI requires real-world results
AI-enabled solutions are now important workflow investments, but healthcare leaders must have clarity around implementation, adoption, and business strategy.
Read Dr. Bonis’ ThoughtsRedefining speed with AI
As AI tools further enter the clinical setting, they can provide huge opportunities for time savings through more efficient decision-making.
Read Yaw’s PerspectiveFrequently Asked Questions About UpToDate Expert AI
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What clinical decision support can UpToDate Expert AI provide?
UpToDate Expert AI is an interactive GenAI-powered clinical reasoning tool grounded in the evidence-based content from UpToDate. It helps you think through cases, clarify concepts, and answer clinical questions. -
Who can purchase UpToDate Expert AI?
UpToDate Expert AI is available to both UpToDate Enterprise and Professional users.
- Hospitals and health systems: UpToDate Expert AI is available to clinicians in select health systems through their UpToDate Enterprise Edition subscription. Contact us to discuss how you and your health system can get access.
- Individual subscribers in the United States and Canada: Visit the UpToDate webstore to subscribe to UpToDate Pro Plus or trainee package with Expert AI.
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Is UpToDate Expert AI available on a mobile device?
Yes, you can access it through desktop or the UpToDate mobile app. -
How is UpToDate Expert AI different from the standard UpToDate solution?
This GenAI solution builds on our legacy of providing trusted clinical answers. It interprets clinical questions, explains reasoning, highlights assumptions, and provides personalized, context-aware recommendations in an intuitive chat format — mirroring a consultation with a trusted expert. -
What content sources does UpToDate Expert AI use to generate responses?
Built on the trusted evidence-based content from UpToDate, UpToDate Expert AI draws exclusively from our rigorously maintained clinical information, and developed with AI standards that prioritize transparency, evidence, and clinical integrity. Every answer is traceable and includes direct links to UpToDate topics. -
How does UpToDate ensure responsible, trusted development of AI capabilities?
Grounded in expert-driven development, our standards ensure AI tools are designed and validated by clinical professionals, reducing errors and providing evidence-based, actionable insights. -
Does UpToDate Expert AI offer CME credits?
Yes, users can earn CME/CE/CPD credits while they search in UpToDate Expert AI and redeem them directly through the platform. UpToDate Expert AI is currently accredited by the Accreditation Council for Continuing Medical Education (ACCME) for physicians, and by the American Association of Nurse Practitioners.
Ready to revolutionize your care delivery with AI?