Every medication decision counts

Every medication decision, whether prescribing, dispensing, counseling, administering treatments, settling policy, or helping patients to manage their conditions, is critical.

The stakes are high: The annual cost associated with medication errors is an estimated $42 billion globally, according to the World Health Organization. With evidence changing daily, you need referential drug information that is evidence-based, continually updated, and easily accessible at the point of care for professionals across the healthcare landscape.

The power of one voice for drug information

Drug solutions, such as UpToDate® Lexidrug™ (formerly Lexicomp®) and Medi-Span®, deliver real-world, evidence-based insights and recommendations to support you when making appropriate drug decisions for your patients and members. Drug insights are also integrated into UpToDate clinical decision support to enable better care decisions and diagnoses. If the same drug information is used across multiple departments, organizations and even industries, then the whole healthcare ecosystem can make unified, evidence-based drug decisions.

UpToDate Lexidrug for Individuals

A personal subscription to UpToDate Lexidrug offers unparalleled referential drug content that empowers you to make the best possible evidence-based medication decisions.
UpToDate Lexidrug For Individuals

UpToDate Lexidrug for Enterprises

Provide access to referential drug content from UpToDate Lexidrug across teams and empower them to make evidence-based medication decisions, even when cases are complex.
UpToDate Lexidrug For Enterprises

Medi-Span Drug Data

Aligned with UpToDate, Medi-Span embedded drug data solutions support medication-related decisions across the care continuum, including dispensing, claims processing, pricing, and reimbursement.
Learn About Medi-Span

Our unified drug information offers the power to…

Trust in consistent information
All the topics covered across the UpToDate solutions undergo the same rigorous editorial process and are aligned to ensure consistency.
Understand specific patient needs
Our drug monographs — each containing details for adult, pediatric, and geriatric populations — equip you to make confident decisions for each unique patient.
Utilize the most current evidence
Lexidrug continuously evolves to provide the latest evidence-based content, and we do so in a way that allows clinicians to treat each patient based on their individual medical needs.
Receive guidance on complex decisions
Go beyond the standard drug information to gain depth where it matters most, and sophisticated guidance that supports patient and member populations, co-morbidities, pregnancy, and more.

"Having a trusted source for drug decisions is critical to delivering safe, high-quality healthcare. Using [UpToDate Lexidrug], I am confident that the information we provide to other healthcare professionals is contributing to the best possible outcomes for our patients."

– Colm Devine, Chief Pharmacist, Letterkenny University Hospital, Ireland

Efficiently access key drug information within clinical decision support

When treating a patient, you need to move quickly while also making the best decisions possible. Likewise, setting policy or evaluating benefits and claims requires precise and efficient choices. Clear, concise drug monographs make it easy to apply the drug information to the decisions at hand. In addition to drug topics, UpToDate grants you access to the following drug databases:

  • General and disease-specific dosing, including evidence-based, off-label dosing
  • Detailed dose adjustments for impaired kidney or liver function, obesity, or toxicity
  • Pediatric and neonatal dosing and drug administration
  • A separate drug interactions program (Lexi-Interact) that provides a more in-depth analysis of drug-drug, herb-drug, and herb-herb interactions
  • Drug adverse effects, warnings, and precautions, including practical details such as premedication information and patient monitoring parameters
  • Drug administration details, including drug brands, available strength, and dosage form information
  • Current FDA Special Alerts and major Health Canada safety communications

The drug information and drug interactions databases in UpToDate and Lexidrug solutions add another level of knowledge to clinical and pharmacological practice, helping improve the quality and safety of care.

Individual Subscription
Individual Subscription
Enterprise Subscription
Enterprise Subscription
Two Asian pharmacists with tablet and pill bottle
Additional solutions with UpToDate Lexidrug
With UpToDate Lexidrug, additional solutions designed for retail pharmacy can enhance efficiency and improve formulary adherence.
Drug reference for retail pharmacy
Provide evidence-based drug content, tools, and tables with an interface geared for the retail environment that allows pharmacists to quickly access the information they need to assist patients.
Learn More
Custom formulary
With thousands of drugs to consider for your patient population and budgetary requirements, having your formulary and policies integrated directly into decision support tools improves safety and efficiency.
Learn More

Insights from the experts

graphic of vials with DNA
Pharmacogenomics and the flawed use of race in recommendations
Race continues to be a consideration – albeit a flawed one – on drug labels and testing recommendations. Our ever-improving knowledge of how genomic factors contribute to the observed differences in medication response should mitigate this.
Read The Article
Woman nurse with facemask looking at IV bag
Supporting effective treatment for infectious disease while combating antimicrobial resistance
By taking a strategic approach to antimicrobial stewardship with evidence-based resources that provide current information on infections and appropriate treatments, healthcare leaders can help guide their clinicians toward combating antimicrobial resistance.
Read The Article
Prescription medicine pill bottle and pills.
The importance of adjusting drug dosing for patient-specific factors 
Despite manufacturers labeling recommending a one-size-fits-all, every patient is different, and medications work differently inside different bodies. This requires a more nuanced, individualized approach to drug dosing.
Read The Article

Explore more insights on drug decision support

  • Article
    Health
    July 11, 2025

    Transforming healthcare with biosimilars: lower costs, greater access, smarter solutions

    Biosimilars reduce healthcare costs, improve access, and drive innovation. Learn how data tools like Medi-Span empower smarter decisions.
    Learn More
  • Article
    Health
    June 24, 2025

    Pharmacy leaders can impact patient care through precision drug alerting

    By getting involved in drug screening reviews, pharmacists can enhance quality, help improve workflow and reduce alert fatigue at their organizations.
    Learn More
  • Article
    Health
    May 30, 2025

    Pharmacists on patient care teams are proving their value by streamlining workflow and drug decisions

    Despite pressures, pharmacists drive efficiency for health systems through formulary communications and cross-functional problem-solving.
    Learn More
  • Article
    Health
    November 20, 2024

    For payers, the future requires building a sustainable data alignment strategy

    Data alignment between payer benefit teams remains a challenge. Leaders need to build sustainable strategies to best understand improvements for efficiencies and member experiences.
    Learn More
Back To Top