Clinical decisions are rarely straightforward

Every patient presents a unique combination of symptoms, risk factors, comorbidities, and treatment considerations. At the same time, the volume of medical evidence continues to grow, making it increasingly difficult to quickly identify what's most relevant to the patient in front of you.

Navigate complex clinical decisions with trusted evidence and AI-assisted reasoning

For decades, physicians have trusted UpToDate® for evidence-based, peer-reviewed clinical recommendations. Now, UpToDate Expert AI builds on that foundation, helping physicians quickly synthesize relevant evidence, navigate clinical uncertainty, and evaluate options with greater clarity.

When the case isn't straightforward

Navigate clinical complexity with confidence. Expert AI helps frame the problem, surface key considerations, and provides clear rationale to help you evaluate options and weigh risks.

When you need a quick answer

Find relevant evidence faster. Expert AI interprets and contextualizes UpToDate content to help you quickly understand what matters most for the patient in front of you.

When your decision needs supporting evidence

Review transparent sources, supporting evidence, and clinical ratione that can be reviewed, verified, and traced back to trusted UpToDate content.

When you're deciding what to do next

Explore follow-up questions, diagnostic considerations, and management options tailored to the patient scenario.

Trusted solutions for Physicians

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UpToDate with Expert AI

UpToDate® delivers evidence-based clinical decision support for medical professionals and small groups. A personal subscription includes expert-reviewed medical content, integrated drug information, mobile access, and tools to help healthcare professionals make informed decisions and improve patient outcomes.
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UpToDate Pro Plus

UpToDate Pro Plus combines trusted, evidence-based clinical content with AI-powered decision support and advanced tools that help clinicians make informed care decisions, streamline prescribing, and stay productive wherever they practice.
UpToDate Pro Plus
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Navigate complex clinical scenarios with the evidence-based AI tool for medical doctors

Get trusted insights most relevant to your scenario at a glance. Built by clinicians and grounded in continuously evaluated, evidence-based content from UpToDate, Expert AI adapts to patient context and synthesizes evidence into clear, actionable responses you can review and apply with confidence at the point of care.

  • Concise, actionable decision support

  • Complex clinical reasoning

  • Patient-specific answers

  • Transparent, traceable AI

Move from question to action fast with clear, concise insights designed for real-world clinical decisions.

  • Make decisions faster: Short, scannable answers highlight potential next steps you can quickly act on at the point of care.
  • Ask questions naturally for quick clarity: Conversational AI feels like consulting a seasoned colleague.
  • Focus on what matters: Expert AI summarizes the relevant clinical details, helping you stay focused on care.
  • Get support wherever care happens: Accessible GenAI support within UpToDate on the web or mobile app for on-the-go clinical insights.
Doctor using UpToDate on mobile device.

Navigate challenging cases with confidence. UpToDate Expert AI reflects the thinking of real clinicians, helping guide decision making in complex scenarios.

  • Simplify complex information: Generate on-demand visuals with Expert AI to interpret evidence quicker.
  • Research deeper when relevant: Jump directly to UpToDate source topics when a case requires deeper review.
  • Build and refine differentials faster: Expert AI helps by structuring differentials and surfacing key evaluations.
  • Work through difficult cases: View management options with rationale that reflects how clinicians think through risks, benefits, and next steps.
Artificial Intelligence Hero

Tailor your care decisions with case-specific insights powered by GenAI that adapts to the context.

  • Turn nuanced questions into next steps: Diagnostic pathways and treatment considerations align to your patient’s context.
  • Validate your approach: Expert AI helps frame clinical problems, flag potential missteps, and explains its reasoning behind the recommendations.
  • See context-aware details: Surfaced therapy options and dosing insights that align with individual patient factors.
  • Determine patient-aligned next steps: Guided prompts suggest contextually relevant follow-up questions.
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Trace answers back to trusted sources you can review, validate, and act on.

  • Act with confidence: Responses are clinically validated and designed to support – not replace – your judgment.
  • Strengthen your reasoning: Practicing clinicians guide how Expert AI interprets and responds to your questions.
  • Verify every recommendation: Clear logic, citations, and reasoning allow you to evaluate options with confidence.
  • Stay aligned with standards: Insights reflect expert-reviewed content and align with clinical best practices.
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Earn Continuing Medical Education (CME) as part of your clinical workflow

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Earn CME while searching for clinical answers
Turn everyday clinical questions into learning opportunities. When you use UpToDate and Expert AI to explore evidence-based information relevant to patient care, you can earn CME as part of your existing workflow, without setting aside additional time for coursework.
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Your vendor is not the risk. Your dependency is.
Find qualifying CME content faster
CME state tagged topics in UpToDate Pro Plus help you quickly identify eligible content for your licensed state. Clearly see which topics count toward state-specific requirements, reduce manual tracking, and streamline the process of earning, documenting, and managing CME credits.
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Explore Plans for UpToDate and UpToDate Pro Plus

Join millions of clinicians worldwide who rely on UpToDate for comprehensive, evidence-based recommendations across specialties and care settings.

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  1. UpToDate Expert AI is currently available in select markets. Access may vary and is offered through participating institutional subscriptions or individual purchase subscriptions. It is a clinical decision support tool in the United States and certain other jurisdictions, and is a reference-only tool in others.
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