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Streptomyces in Nature and Medicine: The Antibiotic Makers
- Publication Year:
- 2007
- Edition:
- 1st
- Author:
- Hopwood, David A.
- Publisher:
- Oxford University Press
- ISBN:
- 978-0-19-515066-7
- Doody Core Title Score:
-
- ()
-
Description
-
Details
Description
This is an insider's account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs.
The book begins by describing how these microbes--the actinomycetes--were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use.
The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, i
The book begins by describing how these microbes--the actinomycetes--were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use.
The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, i
Details
- Platform:
- OvidSP
- Publisher:
- Oxford University Press
- Product Type:
- Book
- Author:
- Hopwood, David A.
- ISBN:
- 978-0-19-515066-7
- Specialty:
-
- Medical Genetics
- Microbiology
- History of Medicine/Science
- Infectious Diseases
- Internal Medicine
- Language:
- English
- Edition:
- 1st
- Pages:
- 272
- Publication Year:
- 2007
- Doody Core Title Score:
-
- ()