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The fully revised 8th Edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland.

  • Reflects the latest advances in the field, including current insights on immune system function, both basic and translational
  • Contains 50 chapters written by leaders in all subfields of immunology
  • Provides extensive coverage of the molecular biology that explains the dynamics underlying immune disorders and their treatment
  • Includes 10 entirely new chapters covering invertebrate and plant immunity, eosinophils, innate lymphoid cells, gamma/delta T cells, NKT and MAIT cells, immunometabolism, maternal-fetal immunology, and more
  • Contains abundant full-color illustrations and tables that provide essential information at a glance
  • Features annual updates from the authors to the VST version, keeping you current with changes in this dynamic field from the experts
  • Selected as a Doody's Core Title™ for 2022!

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  • About the authors
    Martin Flajnik
    Professor, University of Maryland Baltimore School of Medicine
    Dept. of Microbiology and Immunology

    Martin Flajnik graduated from the Pennsylvania State University in 1978 with a BS in Biology. He earned an MS in 1979 and a PhD in 1983 from the University of Rochester (NY) in Microbiology and Immunology. He was a postdoc (and completed his PhD) from 1983-1988 at the Basel Institute for Immunology under Louis Du Pasquier, and rose to professor in his first independent academic position at the University of Miami (FL) (1988-97). He has been a professor at the University of Maryland Baltimore School of Medicine since 1998.

    Honors and Awards
    • "Faculty Member of the Year Award," teaching award sponsored by the Microbiology and Immunology University of Miami undergraduates, 1995
    • Plenary talks at the International Immunology Meetings of 1989 and 1995
    • Co-editor of the journal Immunogenetics since 2001
    • Vice President of the International Society of Developmental and Comparative Immunology (ISDCI) (2001-2007)
    • GPILS teacher of the year, UMB Graduate School, 2008
    • "Immunological Guru” and plenary speaker at the NIH Immunology Retreat, 2010
    • Funded by the NIH continually from 1988-present
    • Contributed a chapter to Fundamental Immunology Editions 5-7 (1992-2012) and co-editor of the 8th Edition (2022)

    Research Interests
    Flajnik's work is centered on the evolution of the adaptive immune system, with the major goal being to understand the origins of adaptive immunity. He was involved in the early biochemical and molecular characterization of lower vertebrate MHC, and has identified several immunoglobulin and T cell receptor isotypes in ectothermic vertebrates. His lab recently has become interested in the evolution of lymphoid tissues.

    Nevil J. Singh
    Assistant Professor
    University of Maryland Baltimore
    Steven M. Holland
    Director, Division of Intramural Research
    NIAID, National Institutes of Health
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