Health October 28, 2026

Medication safety is patient safety. Can AI help strengthen both?

Key Takeaways

  • Retail pharmacies need structured, evidence-based drug information to support consistent medication decisions across every patient touchpoint.
  • AI works best when there’s a strong dispensing foundation. When AI is added to fragmented or inconsistent workflows, it can reinforce variability instead of reducing it.
  • High-risk dosing calls for validated logic and human review.
As AI influences more medication-related information, retail pharmacies need structured medication intelligence and consistent workflows that support review without substituting for pharmacist judgment.

Medication decisions carry consequences across the healthcare ecosystem.

Research shows that medication-related harm affects one in 30 patients and is related to half of all avoidable harm in healthcare. Polypharmacy affects approximately half of older adults worldwide and is associated with a higher risk of multiple adverse health outcomes, with risk increasing as medication burden rises.

Medication decisions also represent the most interconnected workflows in healthcare:

  • Providers prescribe medications and treatments.
  • Payers manage coverage and approvals through formulary and prior authorizations.
  • Digital tools increasingly help guide decision-making or support plan adherence.
  • Patients manage their own adherence to care.
  • Pharmacies validate the prescriptions, dispense, and answer patient questions.

The retail pharmacy sits at an important intersection point between the practical workflows of medication dispensing and the nuanced art of patient care and counseling. AI has potential to support retail pharmacy by automating some workflows, enabling pharmacists to focus more on patient interactions.

However, when AI is introduced into the healthcare decision-making process, it causes concern for many pharmacists and patients alike that health outcomes could be negatively impacted by ungoverned, unvalidated, or clinically unreliable outputs that might be generated.

Guardrails and processes to promote patient safety in the AI era must extend into the pharmacy workflow, where medication information and decisions from across healthcare converge with real-world medication use and patient outcomes.

Pharmacy medication safety starts with a strong dispensing core

Pharmacies cannot reliably expand their role in care unless the medication review and dispensing workflows in place support trained professionals in managing complexity, empowering them to focus attention where it is needed.

Growing expectations for speed, expanded access, and more clinical services can add stress to everyday dispensing activities, and scaling AI-driven workflows may seem like an easy answer to streamline certain tasks. But when AI is layered on top of inconsistent or fragmented processes, it may reinforce variability, rather than reduce it.

“In high-risk domains like medication dosing, trust starts with recommendations grounded in evidence, expert-curated knowledge, and deterministic clinical logic,” explains Staci Hermann, PharmD, MS, FASHP, FACHE, Vice President, Embedded Clinical Decision Support Content at Wolters Kluwer Health. “Ultimately, AI is a tool to support clinical judgment, not replace it. And if it’s reliable, predictable, evidence-based, and fitting naturally within the workflow, you’ll start building the pathway to adoption.”

More information does not guarantee trust or safe medication administration

Among surveyed clinicians, 32% saw medication safety and adherence as a potential use case for AI-enabled tools.

But in the age of AI in healthcare, patient safety depends not only on care decisions but also on the underlying clinical and medication intelligence that helps inform them. In a Wolters Kluwer survey of healthcare professionals, the largest group – 36% – said greater confidence in the underlying therapeutic and medication intelligence was what they needed most to feel confident in AI adoption. Concern over quality outweighed quantity: Only 9% felt that adding more medication data was key.1

One essential element of patient safety is having aligned, evidence-based care and medication decisions across patient touch points. Disparate tools, inconsistent AI-powered decision support, and teams referencing different care recommendations — even within the same organization — can lead to unwarranted care variation or miscommunications. This is especially critical when it comes to medication dosing and AI: Generic LLMs have shown limitations in performing calculations, and even small dosing errors can create meaningful patient safety concerns.

Support for dosing decisions and medication error prevention

Medication safety is top of mind for many healthcare professionals. Wolters Kluwer surveys have found that 41% of physicians and 37% of nurses report using AI to check diagnoses or drug interactions.

Over the course of four years, 31.5% of all safety-related searches in UpToDate® clinical decision support were focused on drug dosing. The most-accessed dosing topics were those with some of the smallest margin for error:

  • 1.61 million searches for Direct Oral Anticoagulants (DOACs)
  • 1.43M for Heparin & Low Molecular Weight Heparin (LMWH)
  • 773K for Warfarin/ Vitamin K Antagonists (VKAs)
  • 673K for Vancomycin
  • 567K for Digoxin toxicity/dosing

Dosing decisions need to be shared among teams and built on medical intelligence, with a “walled garden” of expertly reviewed drug and dosing information to help professionals avoid hallucinations and answers based on unvalidated, open sources. As AI influences more medication-related information, pharmacies need structured medication intelligence and consistent workflows that support review without substituting for pharmacist judgment:

  • UpToDate® Expert AI: Provides conversational, AI-generated answers grounded in expert-authored, peer-reviewed UpToDate content, with transparent access to supporting sources, clinical assumptions, and rationale to support professional review.
  • Medi-Span® Expert AI: Grounds AI-assisted medication workflows in evidence-based intelligence by applying one maintained medication foundation across two paths: AI-ready intelligence for the applications and agents organizations manage, and defined medication workflow agents that Wolters Kluwer provides and supports.

AI-generated outputs in the drug dosing context must be grounded in deterministic dosing logic and supported by human review. Additionally, interaction checks should be presented alongside dosing guidance to help reduce combined risk.

When retail pharmacies extend their medication safety disciplines into AI-enabled medication workflows, they open opportunities to scale AI adoption and discover new efficiencies while still maintaining pharmacist judgment and the trusted oversight expected by patients and consumers.

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  1. Medication Delivery Commercial Healthcare Professionals Survey – 2026. CITE Research for Wolters Kluwer Health. September 2026. N=117.
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