Scale central fill distribution without manual processes and paper trails

High-volume central fill pharmacies often run on tools that weren't built for the job. Master formulation records and compounding records live in spreadsheets and paper files. Controlled substance shipments still require paper DEA Form 222. Distribution across affiliate hospitals depends on manual tracking. Every one of these gaps adds administrative burden, raises compliance risk, and weakens the traceability you need from production to point of delivery.

That risk grows as health systems consolidate and central fill volume climbs. Without standardized data and electronic documentation, a single ingredient recall can become a slow, manual search across sites, and audit preparation drains valuable staff time.

Compounding Exchange closes these gaps. As a web-based, bi-directional, CSOS-compliant platform, it manages the full lifecycle of a compounded preparation, from production through distribution. Affiliate hospitals place orders, track partial shipments, and confirm receipt, while your team gains real-time inventory visibility and complete electronic documentation. Integration with the DEA's Controlled Substance Ordering System (CSOS) eliminates paper DEA 222 forms for controlled substances. Comprehensive recall management lets you instantly identify affected lots, see how much product was distributed, and locate exactly where it went, supporting USP <797> quality assurance guidance and protecting patients at scale.

CSOS compliance

Integrate with the DEA's CSOS to ship controlled substances without paper DEA 222 forms.

Recall management

Instantly identify affected lots, distribution volumes, and locations to protect patients.

Distribution control

Manage orders, partial shipments, and receipts across every facility you serve.

What Compounding Exchange delivers

Compounding Exchange manages distribution as carefully as production. It replaces disparate manual processes with a single, robust system that strengthens safety, simplifies compliance, and improves operational efficiency across your central fill model.
Compounding Exchange Web Feature Image

Central fill distribution software capabilities

  • Bi-directional online ordering

    Compounding Exchange optimizes order placement and fulfillment across multiple facilities. Affiliate hospitals place orders, track partial shipments, and confirm receipt of each delivery through one fully electronic, bi-directional platform. Real-time inventory visibility lets every party order proactively, so producing entities can cross-check open orders against current batch inventory, track in-house transfers, and adjust production to reduce shortages, overages, and waste.

  • CSOS and DEA integration for central fill operations

    The platform integrates with the DEA's Controlled Substance Ordering System (CSOS), eliminating the need for paper DEA Form 222 when shipping controlled substances. For high-volume operations, that's a meaningful reduction in administrative burden and a step toward fully electronic, audit-ready record keeping.

  • Comprehensive recall management

    When an ingredient or material recall occurs, you can instantly identify which lots were affected, how much product was distributed, and precisely where it went. Individual lots of batched preparations can be marked as recalled following endotoxin and sterility testing, so the whole team has insight into a failed lot. This supports USP <797> quality assurance and control guidance and helps you immediately tell the healthcare team about out-of-specification dispensed CSPs.

  • Configurable labeling for safer pharmacy workflows

    Support complex production, including high-alert medications, with highly configurable labels that improve patient safety at the point of administration and withstand all storage conditions. Instead of managing labels in Word documents and Avery label stock with no version control or approval process, you get high-quality labeling integrated within a true compounding workflow.

  • Video auditing for batch compounding

    For large-scale production, still images become impractical. With Video Auditor, you capture the entire compounding process as a complete, auditable video record saved within the compounding record. This delivers a more practical, thorough method for quality review in high-volume settings, including evaluation of environmental excursions and aseptic technique during compounding.

Scale with central fill compounding software

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Expert Insights on IV Workflow Management

See Simplifi+® IV Workflow Compounding Exchange in action

Book a personalized demo to see how a bi-directional, CSOS-compliant platform simplifies central fill ordering, distribution, and compliance across your health system.

What you'll learn:

  • How a bi-directional platform manages the full lifecycle of a compounded preparation, from production to delivery
  • How CSOS integration eliminates paper DEA 222 forms for controlled substances
  • How comprehensive recall management supports USP <797> quality assurance and protects patients
  • How real-time inventory visibility reduces shortages, overages, and waste across facilities
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