Optimizing vancomycin dosing with Bayesian methods
Dose optimization and monitoring of medications are complex. Clinicians must evaluate and act on patient-specific factors that influence pharmacokinetics and pharmacodynamics. Sentri7® Pharmacy supports personalized vancomycin dosing and other medications to enhance patient safety and streamline pharmacy workflows.
Why Bayesian Dosing?
Bayesian Dosing uses patient data and laboratory results to estimate a patient's ability to absorb, process, and clear a drug from their system. Using a clinically validated population model, algorithms adjust the pharmacokinetic and/or pharmacodynamic parameters so that a patient-specific, individualized drug model is built. This individual model is then used to provide a patient-specific dosing recommendation to reach a therapeutic target.
Sentri7 integrates with both PrecisePK and DoseMeRx to review patient-specific parenteral dose recommendations calculated automatically using key clinical data such as patient weight, laboratory values, creatinine levels, and drug administration times.
Vancomycin is one of the most used antibiotics in hospitals today. Traditionally, calculating precise vancomycin doses for patients requires coordination among pharmacists, nurses, and phlebotomists, as well as manual data entry that is time-consuming and prone to errors. Integrated precision dosing solutions with Sentri7 provide an easy path to implement ASHP’s 2020 recommendation for dosing and monitoring vancomycin.