Health September 17, 2026

Improving Penta vaccine uptake through clinical communication in Cameroon

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Key Takeaways

  • In 2023, the Penta 1 to Penta 3 drop-out rate hit 30%, above the recommended threshold of under 10%.
  • Using JBI PACES and the GRiP framework, the team improved 9 out of 10 best-practice communication criteria.
  • Education on adverse events rose from 23% to 71%, and reminder messaging climbed from 15% to 64%.
In Cameroon's Bali Health District, a team used JBI PACES and the GRiP framework to strengthen clinical communication, lifting pentavalent vaccine uptake, improving caregiver understanding, and reducing missed appointments for children under five.

How clinical communication impacts vaccine uptake

In 2024, the Bali Health District in Cameroon faced alarmingly low uptake of the pentavalent (Penta) vaccine among children under five. This vaccine protects against five life-threatening diseases, yet gaps in clinical communication left many caregivers misinformed, hesitant, or unaware of the importance of completing the full vaccination schedule.

In this rural region, where many families travel long distances to access care, communication failures had significant consequences. Caregivers often left Infant Welfare Clinics unclear about follow-up appointments or concerned about side-effects, contributing to high drop-out rates. In 2023, the drop-out rate between Penta 1 and Penta 3 reached approximately 30%, far exceeding the recommended threshold of less than 10%.

Recognizing the need for change, eBASE Africa, with support from JBI, implemented a structured, evidence-based approach to strengthen clinical communication and improve vaccine uptake.

Clinical communication gap

Low uptake of the Penta vaccine was driven by inconsistent and ineffective communication between healthcare providers and caregivers.

Key challenges included:

  • Limited caregiver understanding of vaccine benefits and schedules
  • Misconceptions about side-effects and vaccine safety
  • Lack of structured communication tools or protocols for health workers
  • Missed follow-up appointments due to unclear guidance and lack of reminder
  • Resource constraints impacting community follow-up and engagement

As one nurse reflected, “We just told the mothers to come back in a month — we didn’t explain what the vaccines were for or why it was important to return.

Improving clinical communication with JBI PACES and GRiP

A multidisciplinary team used JBI PACES and the Getting Research into Practice (GRiP) framework to assess current practices and implement targeted, evidence-based strategies.

Key actions included:

  • Conducting a baseline audit of communication practices during Infant Welfare Clinics
  • Developing and implementing a standardized clinical communication protocol aligned with WHO recommendations
  • Training healthcare providers in effective, evidence-based communication techniques
  • Designing and distributing culturally appropriate posters and visual counselling tools
  • Sending over 400 SMS reminders to caregivers to support follow-up attendance
  • Engaging community health workers to track missed appointments and conduct home visits

Visual tools such as laminated flip charts were used to explain vaccination schedules and side-effects, particularly supporting caregivers with low literacy.

We realised it wasn’t just about giving vaccines — it was about how we communicated them,” said Ngem Bede, project lead.

Measuring the impact of clinical communication interventions

A follow-up audit demonstrated significant improvements in communication practices and caregiver engagement.

Key outcomes included:

  • Improvements in 9 out of 10 best practice criteria
  • Education on adverse events increased from 23% to 71%
  • Reminder messaging improved from 15% to 64%
  • Healthcare worker training increased from 25% to 81%
  • Communication materials availability rose from 21% to 75%
  • Drop-out tracking and follow-up significantly improved

Healthcare providers reported increased confidence in communicating with caregivers, while caregivers themselves were more engaged and informed.

Now we don’t just vaccinate, we talk to the mothers, we explain,” shared a nurse.

A caregiver noted:

Before, they would just write a date on the card. Now they explain everything. I don’t miss appointments anymore.”

Future clinical communication measures

The project has established a foundation for sustained improvement and broader scale-up.

Next steps include:

  • Embedding audit and feedback into routine district review processes
  • Expanding the intervention to additional health districts, including Batibo and Bamenda
  • Delivering ongoing refresher training for healthcare workers
  • Integrating communication quality indicators into supervision frameworks
  • Strengthening community engagement through continued use of SMS and local networks

Key clinical communication lessons from Cameroon

This project demonstrates how structured evidence implementation using JBI PACES and GRiP can transform healthcare outcomes through improved communication. By strengthening how healthcare providers engage with caregivers, the initiative increased vaccine uptake, improved understanding, and reduced missed appointments — helping protect more children from preventable diseases.

At its core, the project highlights that effective communication is not just a soft skill, but a critical component of quality care. With its measurable impact and scalable approach, this model provides a roadmap for improving immunization outcomes in similar settings worldwide.

Ready to transform evidence-based practice at your organization? Explore JBI Best Practice Evidence Summaries, or contact your JBI representative.

Explore JBI Best Practice Evidence Summaries
Ngem Bede Yong
Deputy Director, and Clinical Research Consultant, PhD(c), JBI Effective Basic Services Africa Cameroon, Bamenda, Cameroon
Akah Thelma Eni
Public Health Researcher, BSc, JBI Effective Basic Services Africa Cameroon, Bamenda, Cameroon
Lontum Alvin
Research Fellow, BSc, JBI Effective Basic Services Africa Cameroon, Bamenda, Cameroon
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