UpToDate Expert AI on a laptop and mobile device

Fast, trusted clinical AI answers

Clinical questions aren't always straightforward — clinicians need an AI tool that can handle complex decisions. UpToDate® Expert AI delivers fast, reliable answers through a conversational experience that feels like consulting a trusted colleague. Purpose-built for today’s clinicians, it combines the power of generative AI with rigorously vetted, expert-authored content from UpToDate —connecting users to the clinical intelligence needed to make confident, informed care decisions.

UpToDate Expert AI is currently available in select markets. Access may vary and is offered through participating institutional subscriptions or individual purchase subscriptions. It is a clinical decision support tool in the United States and certain other jurisdictions, and is a reference-only tool in others.

Explore Personal Subscription Options
Explore Personal Subscription Options
Learn About UpToDate Enterprise Edition
Learn About UpToDate Enterprise Edition

Clinical intelligence that empowers clinicians to deliver better patient care

UpToDate® Expert AI is generative AI built solely on the trusted, evidence-based UpToDate content created by over 7,600 clinical experts, delivering the nuance, context, and speed clinicians need for actionable, real-world care decisions. Get fast, clear answers to help guide decisions for complex cases, treatment plans, differential diagnoses, drug dosing, and more.

  • Clinical guidance

  • Transparent reasoning

  • Tailored responses

  • Latest features

Support safe care with the GenAI solution built by clinicians, for clinicians.

UpToDate Expert AI delivers trusted insights grounded in the evidence-based recommendations from over 7,600 clinicians, and built with rigorous AI standards that prioritize transparency, evidence, and clinical integrity. Ask questions and get clear, traceable answers that include inline links to UpToDate topics.

Features that connect responses to UpToDate content and clinical expertise:
  • Succinct answers for faster action, with the option to refine questions or ask a follow-up.
  • UpToDate sources and inline links provide clear citations and displays the supporting UpToDate content without leaving the AI search interface.
  • Assumptions provide context and inline nudges help guide clinicians toward asking improved questions for better answers.
  • Drug linking provides relevant drug information in a side panel, and drug dosing insights are grounded in UpToDate and UpToDate® Lexidrug™ content.
  • Voice input for hands-free questions.
UpToDate Expert AI screenshot highlighting Sources feature
"Sources" response section in UpToDate Expert AI.
Designed to support clinical reasoning, not replace it.

Engage in interactive dialogue that delivers more than just insights. Every response from UpToDate Expert AI includes transparent reasoning and clearly stated assumptions, helping you understand not only the recommendations provided, but the rationale behind them.

Features that promote transparency and clinical reasoning:
  • Assumptions frame the question and clarify the clinical problem.
  • A side panel provides supporting links, rationale, facts, and UpToDate topics without leaving workflow.
  • Nudges help clinicians add missing context, like comorbidities or ICU status.
  • Inline sources show referenced UpToDate topics tied directly to statements.
UpToDate Expert AI screenshot highlighting Assumptions feature
“Assumptions”response section in UpToDate Expert AI.
Elevate your clinical decision-making with tailored recommendations

Get nuanced support for working through cases, interpreting evidence, determining care options, and applying insights to patient care. Designed to think like a clinician, UpToDate Expert AI empowers your clinical judgment without replacing it.

Features that support fast understanding and clinical decision making:
  • Succinct, high-quality responses clearly organized into assumptions, direct answers, and clinical context.
  • Tailored visuals simplify complex clinical content.
  • Structured tables help compare care options, such as differential diagnoses.
  • Drug information that’s relevant and doesn’t require sifting through monographs.
UpToDate Expert AI on a laptop with the tables magnified.
Tables in UpToDate Expert AI responses help compare care options.
Always UpToDate

UpToDate Expert AI is constantly evolving through groundbreaking advancements and thoughtful refinements to ensure it remains a trusted, provider-focused solution. With every update, we’re committed to delivering smarter, faster responses that empower clinicians to provide safe, exceptional care.

Our latest updates are:
  • Recent GenAI search enhancements to support more actionable care include: reformatted responses, adding nudge prompts to trigger additional context, inline sources, structured answers, and voice prompts.
  • A side panel provides UpToDate cited sources, drug monographs, dosing details, and graphics within your search interface.
  • Expanded CME/CE/CPD credit accrual to UpToDate Expert AI to support professional development within the workflow.
  • Expanded medication information from UpToDate Lexidrug to support .high-impact drug-related questions, such as adverse reactions, contraindications, and considerations for pregnancy and breastfeeding.
  • Added copy-and-paste functionality to make it easier for clinicians to seamlessly integrate UpToDate insights into their workflows.
  • A new mobile app that puts the power of UpToDate Expert AI within easy reach. Available now for Enterprise users.

Explore the latest in AI in healthcare

UpToDate Expert AI is built by a team of practicing clinicians and healthcare industry experts who help inform and refine the solution for responsible, real-world practice in collaboration with our clinician users and customers. Explore our process and thought leadership behind the tool and the ongoing innovation to help shape the future of patient care.
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Expert perspectives on AI

From our AI validation framework to proprietary reports and insights to thought leadership, explore our approach and perspectives on integrating responsible AI in clinical decision support.
Explore AI Insights
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Conversations on AI

Explore a variety of podcasts, webinars, and thought leadership insights on AI in the healthcare industry from UpToDate clinical and technology experts.
Explore AI Topics
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Trust in the AI era

A clinically-tested AI framework and evaluation process built by practicing clinicians is critical for trusting tools in patient care. Read how Outsell reviewed and validated the UpToDate framework.
Read Their Insights
Physician using UpToDate Expert AI on a mobile device.
Access UpToDate Expert AI on mobile
UpToDate Expert AI — now on mobile — gives clinicians fast, AI‑assisted support for real clinical questions—delivered as a trusted clinical companion that meets enterprise standards for governance and evidence‑based medicine. Designed for true point‑of‑care use, it helps clinicians think through complex scenarios wherever care happens, from the bedside to in between patients or on the go. 
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Trusted by clinicians

  • Trusted and easy

  • Evidence-based trust

  • Clinical support

  • Workflow efficiency

  • Time savings

Stephen Baugh headshot
I have found the UpToDate Expert AI program to be very helpful. It is easy to use, and I trust this particular AI more than I do in general.
Stephen Baugh, MD
Primary Care Physician, Legacy Health
Ben Kilman headshot
We are confident in UpToDate Expert AI because it is intentionally contained within the rigorously curated UpToDate content. This approach avoids the extraneous or potentially erroneous data risks seen in open or non-curated AI models, while maintaining alignment with evidence-based clinical guidance. By building upon the trusted UpToDate foundation, UpToDate Expert AI takes clinical decision support to the next level—enhancing efficiency and delivering tailored, context-aware responses that support providers in delivering the best possible care to our patients.
Ben Kilman, MD, CMIO
North Mississippi Health Services
Katherine Carson headshot
UpToDate is my go to for reinforcing my current practice. I was excited to see the AI update. It has actually helped me formulate my assessment and plan on more complicated patients. Additionally, it provides differential diagnosis to make sure I don’t miss something based on the patient's symptoms. 
Katherine Carson, APRN, CNP
Orthopedic Nurse Practitioner, Sanford Health 
Waye Latack headshot
The new, up-to-date generative features go beyond basic automation; they actually anticipate my needs, drafting content and creating complex layouts in seconds. It feels less like a tool and more like a partner that allows me to focus on strategy instead of grunt work. It has increased my efficiency and freed up valuable hours, making it an indispensable part of my daily workflow! 
Wayne Latack, MD, FACP, FASN
DIO / Director, Internal Medicine Residency Program, Memorial Health Gulfport
Salisia Valentine headshot
I truly appreciate the new [UpToDate® Expert] AI feature. Several of my providers have already reported back that the feature has cut down on ‘searching time’ because they don't have to read multiple articles to find the answer. 
Salisia Valentine, DNP, FNP-C, MSN, RN
Orthopedic Nurse Practitioner, American Family Care

Frequently Asked Questions About UpToDate Expert AI

  • What clinical decision support can UpToDate Expert AI provide?

    UpToDate Expert AI is an interactive GenAI-powered clinical reasoning tool grounded in the evidence-based content from UpToDate. It helps you think through cases, clarify concepts, and answer clinical questions.

  • Who can purchase UpToDate Expert AI?

    UpToDate Expert AI is available to both UpToDate Enterprise and Professional users.

    • Hospitals and health systems: UpToDate Expert AI is available to clinicians in health systems with an enterprise-wide subscription to UpToDate. Contact us to discuss how you and your health system can get access.
    • Individual subscribers: Expert AI is included in select UpToDate personal professional and trainee subscriptions. Availability varies by region — visit the webstore to explore subscription options.

  • Is UpToDate Expert AI available on a mobile device?

    Yes, UpToDate Expert AI is available to all users through the UpToDate mobile app or a mobile web browser. Enterprise users can access through the UpToDate Expert AI mobile app. Visit our mobile apps page for more information.

  • How is UpToDate Expert AI different from the standard UpToDate solution?

    This GenAI solution builds on our legacy of providing trusted clinical answers. It interprets clinical questions, explains reasoning, highlights assumptions, and provides personalized, context-aware recommendations in an intuitive chat format — mirroring a consultation with a trusted expert.

  • What content sources does UpToDate Expert AI use to generate responses?

    Built on the trusted evidence-based content from UpToDate, UpToDate Expert AI draws exclusively from our rigorously maintained clinical information, and developed with AI standards that prioritize transparency, evidence, and clinical integrity. Every answer is traceable and includes direct links to UpToDate topics.

  • How does UpToDate ensure responsible, trusted development of AI capabilities?

    Grounded in expert-driven development, our standards ensure AI tools are designed and validated by clinical professionals, reducing errors and providing evidence-based, actionable insights.

Ready to revolutionize your care delivery with AI?

Explore personal subscription options 

UpToDate Expert AI for medical professionals

Subscribe to UpToDate for fast, clinically grounded decision support with Expert AI, included in select personal subscriptions. Availability varies by region and subscription type.

UpToDate for residents, students, and fellows 

Access Expert AI at special low rates with a personal trainee subscription to UpToDate. Subscribe today and get faster, focused decision support powered by expert-backed AI. Availability varies by region.
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See Pricing

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