Health16 July, 2025

From HIMSS25 Europe: How do clinicians view the advent of real-world evidence?

I’ve spent nearly two decades working in health technology. In this time, around the globe, I’ve met with many public and private healthcare leaders, and those representing large tech companies.

One topic that’s raised consistently is the challenge of navigating change — how can we best support clinicians as they adopt new technologies, workflows, and ways of thinking?

But I believe that what we’re experiencing today is different. This is not just another wave of innovation — instead, we’re witnessing a genuine structural transformation in healthcare, driven by the emergence of technologies we could barely imagine just a few years ago — including artificial intelligence (AI) — but not only AI.

At HIMSS Europe in Paris, presenting on the Tech stage during their Innovation Day program, I explored what this shift might mean – not only for clinicians, but also for healthcare organisations and for the overall healthcare system. One of the most striking developments is the rise of real-world evidence (RWE). While the idea began in the first decade of this century (with the spread of electronic health records), it wasn’t until around 2015 that its scientific value was recognised in major publications.

Institutional uptake accelerated in the years that followed — especially during the pandemic, when big data, AI, and predictive models made it clear that RWE could play a crucial role in guiding decisions during times of uncertainty.

But what makes RWE so revolutionary?

RWE allows health systems to evolve from being service providers to become continuous generators of evidence, creating a foundation for ongoing improvement and systemic learning.

However, the potential of RWE can’t be realised unless it is successfully operationalised. What matters is the transition from real-world data (RWD) to real-world evidence (RWE), and ultimately to real-world answers (RWA).

That’s where the real transformative power lies — not just in having data, but in turning it into timely, trustworthy, and actionable insights that inform both clinical practice and system-level decisions.

What role can clinical decision support play in the real-world evidence ecosystem?

One of the most valuable – and often overlooked- sources of real-world data is the interaction between clinicians and clinical decision support systems (CDSS).

These systems, when widely adopted, not only support decision-making at the point of care but also provide rich insights into:

  • The needs of patient populations
  • The behaviours and questions of clinicians
  • Emerging patterns in care delivery or public health that may not yet appear in formal reporting systems

Clinical search behaviour, for example, can provide early signals of changing disease patterns, shifting clinical priorities, or latent public health events. When these signals are aggregated across millions of interactions, their value multiplies:

  • The sample becomes representative
  • Comparisons become meaningful — across regions, health systems, and even internationally
  • And trends can be analysed over time, supporting benchmarking and quality improvement

In this sense, CDSS data doesn’t just support the clinician — it informs the system. It enables us to understand variability, identify gaps in knowledge or care, and align training, resource allocation, and strategic decisions with actual frontline needs. CDSS thus becomes a critical layer in the RWE ecosystem — not as a replacement for traditional data sources, but as a complementary, real-time, and context-rich source of insight.

What is the role — and responsibility — of global CDSS platforms in shaping the future of care?

With the launch UpToDate® Enterprise Edition, we are entering a new phase in the evolution of clinical decision support.

For the first time, we’re making available aggregated, condition-based usage insights that allow health organisations to better understand how clinicians are engaging with evidence — by specialty, topic, geography, and more.

This opens new possibilities for:

  • Monitoring and reducing unwarranted variation
  • Tracking trends in clinical focus
  • Detecting early signs of system stress or emerging risks
  • Supporting organisational learning and transformation

With over 3 million clinicians using our tools in more than 190 countries, and 1,200 consultations per minute, we have a dataset of extraordinary depth and breadth. But with that scale comes not just capacity — it brings a clear responsibility. As a trusted partner in clinical decision-making, we are committed not only to supporting clinicians but also to contributing to health system resilience, public health readiness, and better outcomes for all populations.

In this new era, clinical decision support is no longer only about answers at the point of care — it’s about helping systems ask better questions, gain insights into their own clinical behaviours, and respond in smarter, faster, and more equitable ways. This is not just an evolution in product. It’s an evolution in purpose — and a shared commitment to better care, everywhere.

In a way, it allows us to close a virtuous circle:

  • Bringing evidence into clinical practice — and at the same time, turning clinical practice back into evidence
  • That is the promise of a learning health system — and that is the future we are committed to building together

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Mariam Khalil Fernández Expert Bio
Clinical Consulting Director, Medi-Span International, Wolters Kluwer Health
Mariam Khalil Fernández is a Clinical Consulting Director for Wolters Kluwer who is discovering opportunities for improvement in healthcare by leveraging IT solutions.
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