Clinical AI is built on innovation, evidence, and expertise

The conversation around healthcare AI is rapidly shifting from experimentation to implementation.

At the point of care, AI is already delivering faster clinical answers and more efficient workflows, fundamentally changing the way healthcare operates.

Amidst these changes and challenges, one constant remains—the need to anchor decisions on trusted clinical evidence for better outcomes and care delivery.

For over 30 years, clinicians have trusted UpToDate when it matters most. Now, the addition of UpToDate® Expert AI is carrying that legacy forward, merging innovation with clinical expertise.

Innovation, evidence, expertise. The future of AI in clinical decision support.

Conversations on AI and innovation 

Explore our library of podcasts and webinars to hear more conversations and perspectives on AI in healthcare from UpToDate clinical and product leaders.
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Trust is the new differentiator in clinical AI. Get the report from Outsell.
Clinicians and leaders are demanding evidence-based, rigorously evaluated clinical systems to help confidently inform care decisions. In a report, Outsell independently validates how UpToDate extends decades of trusted clinical rigor into the AI era.
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Get The Report

Can AI clinical be trusted? Validation must have rigorous standards

Clinicians should know how trustworthy their AI is.

AI-generated clinical content must go beyond technical performance and familiar measurement tools—especially when patient care is on the line.

This is how UpToDate® Expert AI was built. Members of the clinical and product teams collaborated to develop a clinically useful, innovative approach to AI search to support complex, nuanced care questions built on trusted, expert-created content.

Video Thumbnail: Why is it so critical to validate clinical AI tools?
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Whitepaper: A measured approach to evaluating clinical AI at the point of care

Explore how UpToDate Expert AI was purpose-built for healthcare and is assessed for clinical usefulness, knowledge integrity, and potential risks.
Read The Whitepaper
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Clinical intelligence for the AI era requires both expert and machine

For the clinical team at UpToDate, monitoring the quality of AI-generated responses should always fall on trusted, human expertise. Learn about the Clinical Intelligence Model.
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Building the bridge: GenAI and clinical knowledge

Get a special report by Dr. Sheila Bond on how UpToDate is bridging the rigor of clinical knowledge and GenAI innovations. Read our philosophy and the systems built to make GenAI clinically dependable for the point of care.
Read The Whitepaper

AI-powered clinical answers

UpToDate Expert AI on a laptop
Explore UpToDate Expert AI
UpToDate® Expert AI provides fast, targeted guidance to support evaluation, diagnosis, drug dosing, and treatment. Align your care teams with AI-powered insights sourced directly from UpToDate, authored and validated by clinicians, and purpose-built for modern workflows.
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Explore more on the future of AI in clinical decision support

  • Press Release
    Health
    May 19, 2026

    Wolters Kluwer Medi-Span selected to provide personalized medication decision support at The Christie NHS Foundation Trust

    Roll-out at largest EU cancer center marks first Medi-Span NHS implementation.
    Learn More

  • Key Challenges

  • Whitepapers

  • Our Expertise

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A generational shift in the workforce
The intersection of innovation, generational workforce shifts, and the emergence of GenAI is driving a new era of clinical information retrieval. Access point-of-care insights.
Get The UpToDate Report
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Shifting patient expectations
Patients expect more involvement in their care. Including the patient on the care team, with shared, AI-enabled evidence at the center, equips teams for more aligned decisions.
Read The Expert Insight
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Managing risk and shifting regulation
As healthcare professionals increasingly use GenAI tools in administrative work and at the point of care, leaders must implement usage policies to minimize risk to security and patient care.
Read The Expert Insight
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Healthcare AI shouldn’t be an ‘either-or’ decision
AI in clinical decision support solutions shouldn't mean compromising between speed, evidence, and trust. Deliver AI solutions that enhance decision-making without tradeoffs.
Read The Whitepaper
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Integrating responsible clinical generative AI at the point of care
Artificial intelligence tools represent an exciting new frontier in healthcare, but identifying a responsible, expert content partner is key to clinician adoption.
Access The Whitepaper
Female surgeon and male doctor walk through hospital hallway, consulting digital tablet computer while talking about patient's health
The role of real-world evidence in informing clinical decision-making
Numerous AI-powered tools are now available to support clinicians. Health leaders must determine which can cut through the noise to provide the latest evidence-based information for teams.
Access The Whitepaper
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Governance empowers care teams in an AI-driven future
AI governance operationalized for the point of care helps enable clinicians and patients to align on shared, evidence-based insights while protecting against clinician deskilling. Read the article from Dr. Amanda Heidemann.
Read The Article
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Seeing clinical value from AI requires real-world results
AI-enabled solutions are now important workflow investments, but healthcare leaders must have clarity around implementation, adoption, and business strategy.
Read Dr. Bonis’ Thoughts
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Redefining speed with AI
As AI tools further enter the clinical setting, they can provide huge opportunities for time savings through more efficient decision-making.
Read Yaw’s Perspective

Ready to revolutionize your care delivery with AI?

UpToDate® Expert AI is purpose-built for healthcare and clinical workflows, delivering fast, evidence-based answers built on trusted UpToDate content. Get started with a personal subscription or provide access to your entire clinical staff across your organization.
Learn About UpToDate Expert AI

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Expert AI for medical professionals

Subscribe to UpToDate for fast, clinically grounded decision support with Expert AI, included in select personal subscriptions. Availability varies by region and subscription type.

UpToDate for residents, students, and fellows

Access Expert AI at special low rates with a personal trainee subscription to UpToDate. Subscribe today and get faster, focused decision support powered by expert-backed AI. Availability varies by region.
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