UpToDate Expert AI is designed for clinical use

Transparent reasoning

Provides clear, transparent clinical reasoning, including assumptions and cited sources.

Evidence-based foundation

Pulls exclusively from expert-authored, peer-reviewed UpToDate knowledge.

Source Integrity

Does not use the open web, advertisements, or commercially influenced sources.

Clinical oversight

Governed by clinician-defined guardrails and continuous clinical validation.

UpToDate Pro Plus: Get fast, concise clinical insights with the evidence-based AI tool for medical doctors

Access evidence-based clinical knowledge and tools to help you treat and advise any patient, wherever care happens. Compare package options, including our traditional UpToDate solution and the AI-enhanced UpToDate Pro Plus package. 

UpToDate

$579 / year
Starting Price
Purchase
Purchase

Featuring Expert AI

UpToDate Pro Plus

$699 / year
Starting Price
Purchase
Purchase

UpToDate Content and Tools

Add-on option

Add-on option

UpToDate Expert AI

Real-time decision support at the point of care with UpToDate Expert AI

Built by clinicians and grounded in trusted UpToDate content, Expert AI reflects real-world clinical reasoning with transparent sourcing, stated assumptions, and clear decision-making logic built into every answer.

  • Concise, actionable decision support

  • Complex clinical reasoning

  • Patient-specific answers

  • Transparent, traceable AI

Move from question to action fast with clear, concise insights designed for real-world clinical decisions.

Make decisions faster: Short, scannable answers highlight potential next steps you can quickly act on at the point of care.

Ask questions naturally for quick clarity: Conversational AI feels like consulting a seasoned colleague.

Focus on what matters: Expert AI summarizes the relevant clinical details, helping you stay focused on care.

Get support wherever care happens: Accessible GenAI support within UpToDate on the web or mobile app for on-the-go clinical insights.

doctor consulting tablet

Navigate challenging cases with confidence. Expert AI reflects the thinking of real clinicians, helping guide decision making in complex scenarios.

Simplify complex information: Generate on-demand visuals with Expert AI to interpret evidence quicker.

Research deeper when relevant: Jump directly to UpToDate source topics when a case requires deeper review.

Build and refine differentials faster: Expert AI helps by structuring differentials and surfacing key evaluations.

Work through difficult cases: View management options with rationale that reflects how clinicians think through risks, benefits, and next steps.

Artificial Intelligence Hero

Tailor your care decisions with case-specific insights powered by GenAI that adapts to the context.

Turn nuanced questions into next steps: Diagnostic pathways and treatment considerations align to your patient’s context.

Validate your approach: Expert AI helps frame clinical problems, flag potential missteps, and explains its reasoning behind the recommendations.

See context-aware details: Surfaced therapy options and dosing insights that align with individual patient factors.

Determine patient-aligned next steps: Guided prompts suggest contextually relevant follow-up questions.

Doctor and patient in conversation in hospital hallway looking at digital tablet

Trace answers back to trusted sources you can review, validate, and act on.

Act with confidence: Responses are clinically validated and designed to support – not replace – your judgment.

Strengthen your reasoning: Practicing clinicians guide how Expert AI interprets and responds to your questions.

Verify every recommendation: Clear logic, citations, and reasoning allow you to evaluate options with confidence.

Stay aligned with standards: Insights reflect expert-reviewed content and align with clinical best practices.

Serious male doctor in eyeglasses sitting at the table and typing on laptop computer in office

Continuing Medical Education

Medical students smile during meeting in conference room
Earn CME as you ask clinical questions with UpToDate Expert AI

Seamlessly earn CME as you explore clinical questions, review evidence, and work through differentials as part of your everyday workflow.


Expert AI supports real‑time clinical reasoning as well as ongoing professional development. As an ACCME‑accredited AI‑powered clinical decision support solution, Expert AI offers a fully certified CME experience.

Continuing Medical Education

Frequently Asked Questions

  • What’s the difference between UpToDate and UpToDate Pro Plus?

    UpToDate provides trusted, evidence‑based clinical information and tools. UpToDate Pro Plus includes everything in UpToDate plus Expert AI, the Kidney Dosing Tool, Rx Transitions for Mental Health, and MobileComplete.

  • In what countries is UpToDate Pro Plus available?

    UpToDate Pro Plus featuring Expert AI is currently available only in the United States and Canada.

    Complete the form at the bottom of the page to get notified when we roll out UpToDate Pro Plus to your country.

  • What medical specialties does UpToDate cover?

    UpToDate covers 25 specialties, including internal medicine subspecialties, pediatrics, OB/GYN, general surgery, psychiatry, and more, providing extensive insights for diverse medical needs.

  • Can I access UpToDate on a mobile device?

    Yes. UpToDate personal subscriptions include access through our intuitive mobile app and web browser for seamless access to our evidence-based medical resource anytime, anywhere. And, with MobileComplete included in an UpToDate Pro Plus subscription, you can download clinical content onto your mobile device for use offline.

  • How do I purchase a subscription to UpToDate or UpToDate Pro Plus?

    To subscribe, visit the UpToDate webstore, select your professional role, and choose your desired UpToDate or UpToDate Pro Plus package along with your subscription term.

  • What is the pricing for a personal subscription to UpToDate?

    You can compare package options and pricing directly on the UpToDate webstore,

  • How is UpToDate Expert AI different from other AI tools?

    Unlike certain free GenAI tools that serve ads or may prioritize content based on commercial interests, UpToDate Expert AI:

    • Pulls exclusively from peer‑reviewed, expert‑authored UpToDate content
    • Embeds clinician‑defined guardrails
    • Applies continuous clinical validation
    • Focuses solely on clinical care and evidence‑based insights

  • What safeguards does UpToDate use for AI in clinical care?

    Expert AI includes:

    • Transparent sourcing
    • Embedded guardrails
    • Expert‑in‑the‑loop oversight
    • Rigorous internal validation to support relevant, evidence‑based output

  • In what countries is UpToDate Pro Plus available?

    UpToDate Pro Plus featuring Expert AI is currently available only in the United States and Canada.

    Complete the form at the bottom of the page to get notified when we roll out UpToDate Pro Plus to your country.

  • How can I get access to the Expert AI tool?

    If you have a personal subscription to UpToDate Pro Plus, a personal trainee subscription within the US or Canada, or if you have Expert AI access through your health system, you can use Expert AI easily through your UpToDate account. Sign in to UpToDate with your credentials and click the Expert AI button next to the search bar.

  • How do I upgrade to UpToDate Pro Plus if I’m an existing subscriber?

    To upgrade your existing UpToDate subscription, visit uptodate.com, log in to your account, and select the "Upgrade to UpToDate Pro Plus" button.

  • Does UpToDate provide drug information?

    Yes. All personal UpToDate subscriptions include select drug content from our integrated drug reference, UpToDate Lexidrug, including:

    • Select medication monographs with information on dosing, adverse reactions, preparations, contraindications and warnings, medication safety issues, pharmacology, dietary considerations, administrations, and more.
    • Drug-to-drug interactions tool

    This content helps support informed prescribing decisions.

  • Does the UpToDate Expert AI platform help doctors with treatment planning?

    Yes. Expert AI supports you as you think through potential diagnoses and treatment approaches. It helps by structuring differentials, surfacing key evaluations, and highlighting treatment considerations. Responses are grounded exclusively in expert‑authored UpToDate knowledge with transparent sourcing that empowers your clinical judgment.

  • Does UpToDate offer continuing medical education credits for doctors?

    Yes. UpToDate is accredited by leading medical organizations around the globe and is eligible for AMA PRA Category 1 Credit™ in the U.S. and internationally. Learn why medical professionals choose UpToDate for CME/CE/CPD. 

  • How do I redeem CME/CE/CPD credits through UpToDate?

    Yes. Earning and redeeming credits through UpToDate is a straightforward process and does not require tests, fees, or the use of a third-party provider. You can redeem credit right from your mobile device, including through the UpToDate mobile app, 24 hours a day, 7 days a week. Check out our training videos for guidance.

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UpToDate: Trusted clinical solutions for individuals, enterprises, and everything in between

AI Powered decision support for clinicians
Make confident diagnosis and treatment decisions with convenient, personal access to UpToDate Pro Plus, available for individual professional subscribers in the United States and Canada.

Purchase Now
Clinical GenAI for residents, students, fellows
UpToDate Expert AI is now included in trainee subscriptions. Access trusted, evidence-based clinical insights through an interactive GENAI experience designed to enhance learning and decision making.

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Multi-user subscription option for hospitals and institutions
We offer enterprise subscriptions for provider organizations looking to align care teams and health professionals with the latest evidence-based clinical decision support for consistent, improved health outcomes. 
Explore UpToDate Enterprise
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