The HPV vaccine: A powerful tool in cancer prevention

Promoting HPV vaccination: The role of healthcare providers and administrative leaders

Administrative and clinical leaders play a critical role in reducing HPV infections and associated cancers by making HPV vaccination accessible to all. But there have been some challenges to implementing proactive and preventive healthcare with the HPV vaccine.

Supporting access and affordability

Ideally, all patients should have access to evidence-based cancer prevention. Unfortunately, HPV is the most expensive of the routinely recommended pediatric vaccines. In the U.S. the vaccine can cost upwards of $200 before insurance. The financial returns can also be low for certain providers.

This means administrators can play a key role in addressing disparities in access to care. Clinical leaders can reduce hurdles by negotiating vaccine coverage and by ensuring adequate reimbursement for providers, who can then provide access to their communities.

Research released in 2025 by International Agency for Research on Cancer (IARC) shows that a single dose of the HPV vaccine provides long-lasting protection against HPV infection, even 15 years after vaccination. This finding highlights potential cost savings for healthcare systems, enabling broader vaccine access or enhanced screening services.

Addressing stigma and social determinants of health

When the vaccine first became available, some people had concerns that its use could encourage sexual activity, particularly in young people. This concern has resulted in social stigma around the vaccine and raised parents’ concerns. However, studies support a different perspective. Parents report a lack of confidence in vaccine decision-making, a desire for more information, and a dissatisfaction with provider encounters, along with concerns around necessity and safety. Clinical leaders have a unique opportunity to promote accurate information and encourage shared decision-making. Access to evidence-based solutions can assist here—in 2025, patient education on HPV vaccines and screenings were accessed within UpToDate® over 64,000 times.

Demographic factors like social determinants of health can also influence HPV awareness. A recent study found significant variation in understanding the connection between the virus and cancer based on educational level and race.

Regarding awareness of HPV vaccines:

• Less than high school 34.7%
• College degree or higher 74.7%
• Asian individuals 48.4%
• White individuals 68.2%

Regarding knowledge that HPV causes cervical cancer (among adults aware of HPV):

• Less than high school 51.7%
• College degree or higher 84.7%
• Black individuals 66.0%
• Asian individuals 77.9%

Evidence-based care can effectively promote the screening and treatment of HPV-related cancers, but disparities exist. Black and Hispanic populations, as well as women in low-resource areas, are much less likely to have access to evidence-based care and, thus, have higher rates of mortality. This finding is significant, since access to evidence-based care contributes to differences in patient outcomes and the outcome of cancer is preventable.

Fostering a healthy patient-provider relationship

Progress in increasing HPV vaccination rates and preventive care will rely on a healthy patient-provider relationship.

Administrators should encourage providers to listen to patients’ health goals, objections, and concerns, so that they can work together to create an acceptable vaccination plan. This effort includes facilitating clinicians’ access to the tools, content, and technology that support personalized and effective conversations with patients.

Clinical leaders have the opportunity to reverse HPV-attributable cancer trends through the awareness of the HPV vaccine, screening, and prevention. Success will rely on focusing on preventive care and harnessing AI to support advanced patient engagement programs and tracking outcomes in care populations to optimize results.

To unlock the full potential of advancing women’s health, a holistic strategy is critical in addressing vital areas like HPV vaccination, maternal mortality, and menopause management. Get more detailed insights in the UpToDate Point of Care Report, “Leveraging AI for prevention,” and in a webinar presented to the Scottsdale Institute, where experts dig deeper into solutions for these pressing challenges.